Dynamic changes of striatal neurotransmitter systems activity cause changes in behavioral non-convulsive disorders of depressive nature in the course of chronic seizure activity formation in kindling model of epileptogenesis

Epilepsy is a chronic neurological disease characterized by recurrent behavioral seizures and affects approximately 1% of the global population. causes seizures, which are temporary changes caused disordered, synchronized, rhythmic activations specific populations neurons in brain. Depressive disorders one most common comorbid patients with epilepsy, yet they remain undiagnosed untreated. The aim study to investigate severity non-convulsive swimming emotional behavior mnemonic processes rats kindling model epilepsy under conditions modulation neurotransmitter systems caudate nuclei. It was found that dynamics picrotoxin-induced rats, impaired behavior, learning memory abilities, as well dysfunctions, correlates recorded. has been proven detected behaviors progressed formation were maximal at stages completed postkindling. obtained data demonstrate key role striatum disorders. On 18th day, pro-convulsive noted, confirmed enhancement GABAergic inhibition dopaminergic neurotransmission along its cholinergic mediation. completion mechanisms. In postkindling stage, activation activity observed. author considers be an experimental basis for feasibility testing clinical diagnostic effects terms dynamic monitoring during interictal periods, possible corrective pharmacological case certain intrastriatal neurotransmission.